What data is included?

Open PHACTS brings together the data sources you already use, including ChEBI, ChEMBL, ChemSpider, ConceptWiki, DisGeNET, DrugBank, Gene Ontology, neXtProt, UniProt and WikiPathways. Through Open PHACTS, you have access to all of this data in a single, integrated infrastructure.

Metadata about data provenance is also integrated into the Open PHACTS Discovery Platform, so you can always verify exactly where the information you see comes from.

You can access this data through the Open PHACTS Open PHACTS Explorer, other Applications, and integrate it into your Workflows.

Current data sources

The complete list of data sources currently integrated by Open PHACTS is as follows:

Dataset Downloaded Version Dataset Licence
ChEBI 04 Mar 2015 Release 125 CC-BY-SA 3.0
ChEMBL 18 Feb 2015 ChEMBL 20 CC-BY-SA 3.0
ConceptWiki 12 Dec 2013
DisGeNET 31 Mar 2015 Version 2.1.0 Open Database License
DrugBank 19 Feb 2015 Version 4.1 CC-BY-NC 4.0
ENZYME 02 Feb 2015 Release 2015_1 No modifications
FDA Adverse Events (FAERS) 09 July 2012 Public Domain (CC0)
Gene Ontology 04 Mar 2015 CC-BY 4.0
Gene Ontology Annotations 17 Feb 2015 CC-BY 4.0
neXTProt 01 Feb 2014 v1.0 CC-BY-ND 3.0
SureChEMBL Mar 2015 Terms
UniProt (manually curated entries) 28 Jan 2015 Release 2015_1 CC-BY-ND 3.0
WikiPathways 20 Mar 2015 v20150312 CC-BY 3.0

Chemical compounds from these sources are validated and normalised through the Open PHACTS Chemical Registry, which also integrates identifiers and adds synonyms from ChemSpider. Physicochemical properties are predicted by the ACD/Labs Percepta Platform.

How can Open PHACTS data be used?

Using the Open PHACTS Discovery Platform interfaces, anyone may access, interact with and analyse all Open PHACTS datasets for the purposes of research and development. We have confirmed with the licence holders that this includes the development and commercialisation of pharmaceuticals.

What else can I do with Open PHACTS datasets?

It depends on the dataset licence. Data integrated by Open PHACTS retains the licensing of the original data resources, as listed above, with two exceptions:

Some datasets may therefore be downloaded from Open PHACTS in their entirety, but others may not. Some licences also restrict what you may do with datasets you have downloaded. It is your responsibility to make sure that you comply with all licence terms. We recommend taking a close look at the licensing terms and conditions of any datasets you are interested in.